Cholesterol Lipoprotein (a) Study:
- History of cardiovascular disease (heart attack and/or stents with an underlying comorbidity condition) and very elevated Lp(a) concentration
- Subjects should also be currently taking a statin or documented statin intolerance

Heart Failure Study:
- Diagnosis of heart failure (NYHA Class II-IV)
- LVEF > 40% documented by echocardiography within 12 months

Hypertension with Chronic Kidney Disease:
- Systolic Blood Pressure over 140
- Mild to moderate Chronic Kidney Disease (eGFR between 25 and 75)
- Must be taking an ACE or an ARB

COPD (Chronic Obstructive Pulmonary Disease):
- Eosinophil count greater than 300
- Use of ICS-based triple COPD standard of care
- At least 2 moderate COPD exacerbations within 12 months

Weight Loss:
- Age 55 or above
- Established Cardiovascular Disease (prior MI{myocardial infarction}/heart attack, prior stroke, symptomatic peripheral arterial disease {PAD})
- No heart attack, stroke, or hospitalization for unstable angina or transient ischemic attack within 60 days prior to screening
- No treatment with any GLP-1 medications within 90 days before screening
- No major depressive disorder, severe psychiatric disorder, or history of suicidal attempt
- No history of pancreatitis

Migraine study:
Over 18 years of age
1 year history of chronic migraine
Age of onset of migraines prior to 50 years of age.
Migraine attacks lasting 4 -72 hours if untreated.
At least 15 headache days per month over the last 3 months.

Hypertriglyceridemia/Very High Triglycerides:
Research Study for patients that have triglycerides over 500 on more than one occasion and on a statin medication

Women’s Ischemia Trial:
Females must have a normal heart catheterization within 5 years but have signs and/or symptoms of heart issues (chest pain, shortness of breath, etc.)

Cardiovascular Disease, Chronic Kidney Disease, Systemic Inflammation:
- Age ≥ 18
- eGFR ≥ 15 and < 60
- MI, cardiac revascularization, ≥50% stenosis in major coronary artery, stroke, carotid revascularization, ≥50% stenosis in carotid artery, peripheral arterial disease (PAD) with claudication (from ABI testing), PAD with ≥ 50% stenosis, peripheral artery revascularization, or lower extremity amputation at or above the ankle due to atherosclerotic disease
- No chronic or intermittent dialysis
- No diagnosis of HIV, HEP C, or HEP B