Heart Failure Study:
- Diagnosis of heart failure (NYHA Class II-IV)
- LVEF > 40% documented by echocardiography within 12 months

Hypertension with Chronic Kidney Disease:
- Systolic Blood Pressure over 140
- Mild to moderate Chronic Kidney Disease (eGFR between 25 and 75)
- Must be taking an ACE or an ARB

COPD (Chronic Obstructive Pulmonary Disease):
- Eosinophil count greater than 300
- Use of ICS-based triple COPD standard of care
- At least 2 moderate COPD exacerbations within 12 months

Cardiovascular and Type II Diabetes with Obesity:
- Age 55 or above
- Established Cardiovascular Disease (prior MI{myocardial infarction}/heart attack, prior stroke, symptomatic peripheral arterial disease {PAD})
- No heart attack, stroke, or hospitalization for unstable angina or transient ischemic attack within 60 days prior to screening
- No treatment with any GLP-1 medications within 90 days before screening
- No major depressive disorder, severe psychiatric disorder, or history of suicidal attempt
- No history of pancreatitis

Hypertriglyceridemia/Very High Triglycerides:
Research Study for patients that have triglycerides over 500 on more than one occasion and on a statin medication